Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa
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چکیده
منابع مشابه
Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa
3-Alkyl pyridinium alkaloids (3-APAs) are common secondary metabolites in marine sponges of the order Haplosclerida. In recent years, our laboratory has isolated and synthesized several new members of this family such as haliclamines C-F, viscosamine, viscosaline and a cyclic monomer. All of them were isolated from the Arctic sponge Haliclona viscosa collected in Spitsbergen, Norway. In this ar...
متن کاملHaliclocyclin C, a New Monomeric 3-Alkyl Pyridinium Alkaloid from the Arctic Marine Sponge Haliclona viscosa
In recent years, a number of novel 3-alkyl pyridinium alkaloids were identified from the crude extract of the Arctic marine sponge Haliclona viscosa [1 – 5]. The material available from this sponge was limited by the small size of the individuals, their slow growth rate and the effort to sample substainably in the Arctic ecosystem. A new refinement of the spectroscopic methods led to improved r...
متن کاملHaliscosamine: a new antifungal sphingosine derivative from the Moroccan marine sponge Haliclona viscosa
In the aim of searching for new antifungal products from marine origin, we have isolated a sphingosine derivative, (9Z)-2-amino-docos-9-ene-1,3,13,14-tetraol (Haliscosamine) from the Moroccan sea sponge Haliclona viscosa using bio-guided (antifungal) HPLC methods. The molecular structure of this compound was elucidated by spectrometric techniques IR, UV, MS and NMR. The isolated metabolite show...
متن کاملNucleosides from the marine sponge Haliclona sp.
Three known nucleosides were isolated from the sponge Haliclona sp. The structures were established on the basis of NMR data and comparison with those reported, and chemotaxonomic relationships of the sponge nucleosides were discussed.
متن کاملStructure Elucidation of Submilligram Quantities of Natural Products – Application to Haliclamines G and H from the Arctic Marine Sponge Haliclona viscosa
Two new haliclamines were identified directly from the crude extract of the Arctic sponge Haliclona viscosa using improved chromatographic conditions and a detailed knowledge about the fragmentation pattern of haliclamines. These are haliclamine G (1) with two alkyl chains of equal length (10 methylene groups) and haliclamine H (2) with alkyl chains of 10 and 12 methylene groups. Due to the lim...
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ژورنال
عنوان ژورنال: Marine Drugs
سال: 2010
ISSN: 1660-3397
DOI: 10.3390/md8030483